Improving the system capacity of broadband services using multiple high-altitude platforms

A method of significantly improving the capacity of high-altitude platform (HAP) communications networks operating in the millimeter-wave bands is presented. It is shown how constellations of HAPs can share a common frequency allocation by exploiting the directionality of the user antenna. The system capacity of such constellations is critically affected by the minimum angular separation of the HAPs and the sidelobe level of the user antenna. For typical antenna beamwidths of approximately 5/spl deg/ an inter-HAP spacing of 4 km is sufficient to deliver optimum performance. The aggregate bandwidth efficiency is evaluated, both theoretically using the Shannon equation, and using practical modulation and coding schemes, for multiple HAP configurations delivering either single or multiple cells. For the user antenna beamwidths used, it is shown that capacity increases are commensurate with the increase in the number of platforms, up to 10 HAPs. For increases beyond this the choice of constellation strategy becomes increasingly important

Substrate induction and glucose repression of maltose utilization by Streptomyces coelicolor A3(2) is controlled by malR, a member of the lacI-galR family of regulatory genes

malR of Strepomyces coelicolor A3(2) encodes a homologue of the Lacl/Galr family of repressor proteins, and is divergently transcribed from the malEFG gene cluster, which encodes components of an ATP-dependent transport system that is required for maltose utilization. Transcription of malE was induced by maltose and repressed by glucose. Disruption or deletion of malR resulted in constitutive, glucose-insensitive malE transcription at a level markedly above that observed in the parental malR+ strain, and overproduction of MalR prevented growth on maltose as carbon source. Consequently, MalR plays a crucial role in both substrate induction and glucose repression of maltose utilization. MalR is expressed from a single promoter with transcription initiating at the first G of the predicted GTG translataion start codon

Extreme events in two dimensional disordered nonlinear lattices

Spatiotemporal complexity is induced in a two dimensional nonlinear disordered lattice through the modulational instability of an initially weakly perturbed excitation. In the course of evolution we observe the formation of transient as well as persistent localized structures, some of which have extreme magnitude. We analyze the statistics of occurrence of these extreme collective events and find that the appearance of transient extreme events is more likely in the weakly nonlinear regime. We observe a transition in the extreme events recurrence time probability from exponential, in the nonlinearity dominated regime, to power law for the disordered one.Comment: 5 figures, 5 page

Exploring the Expression of Cardiac Regulators in a Vertebrate Extremophile: The Cichlid Fish Oreochromis (Alcolapia) alcalica

Although it is widely accepted that the cellular and molecular mechanisms of vertebratecardiac development are evolutionarily conserved, this is on the basis of data from only a fewmodel organisms suited to laboratory studies. Here, we investigate gene expression during cardiacdevelopment in the extremophile, non-model fish species, Oreochromis (Alcolapia) alcalica. Wefirst characterise the early development of O. alcalica and observe extensive vascularisation across the yolk prior to hatching. We further investigate heart development by identifying andcloning O. alcalica orthologues of conserved cardiac transcription factors gata4, tbx5, and mef2cfor analysis by in situ hybridisation. Expression of these three key cardiac developmentalregulators also reveals other aspects of O. alcalica development, as these genes are expressed indeveloping blood, limb, eyes, and muscle, as well as the heart. Our data support the notion that O.alcalica is a direct-developing vertebrate that shares the highly conserved molecular regulation ofthe vertebrate body plan. However, the expression of gata4 in O. alcalica reveals interestingdifferences in the development of the circulatory system distinct from that of the well-studiedzebrafish. Understanding the development of O. alcalica embryos is an important step towardsproviding a model for future research into the adaptation to extreme conditions; this is particularlyrelevant given that anthropogenic-driven climate change will likely result in more freshwaterorganisms being exposed to less favourable conditions

Increasing eigenstructure assignment design degree of freedom using lifting

This paper presents the exposition of an output-lifting eigenstructure assignment (EA) design framework, wherein the available EA design degrees of freedom (DoF) is significantly increased, and the desired eigenstructure of a single-rate full state feedback solution can be achieved within an output feedback system. A structural mapping is introduced to release the output-lifting causality constraint. Additionally, the available design DoF can be further enlarged via involving the input-lifting into the output-lifting EA framework. The newly induced design DoF can be utilised to calculate a structurally constrained, causal gain matrix which will maintain the same assignment capability. In this paper, the robustification of the output-lifting EA is also proposed, which allows a trade-off between performance and robustness in the presence of structured model uncertainties to be established. A lateral flight control benchmark in the EA literature and a numerical example are used to demonstrate the effectiveness of the design framework

Next-to-leading BFKL phenomenology of forward-jet cross sections at HERA

We show that the forward-jet measurements performed at HERA allow for a detailed study of corrections due to next-to-leading logarithms (NLL) in the Balitsky-Fadin-Kuraev-Lipatov (BFKL) approach. While the description of the d\sigma/dx data shows small sensitivity to NLL-BFKL corrections, these can be tested by the triple differential cross section d\sigma/dxdk_T^2dQ^2 recently measured. These data can be successfully described using a renormalization-group improved NLL kernel while the standard next-to-leading-order QCD or leading-logarithm BFKL approaches fail to describe the same data in the whole kinematic range. We present a detailed analysis of the NLL scheme and renormalization-scale dependences and also discuss the photon impact factors.Comment: 15 pages, 9 figures, new title, NLL-BFKL saddle-point approximation replaced by exact integratio

Worse than HIV' or 'not as serious as other diseases'? Conceptualization of cervical cancer among newly screened women in Zambia

Invasive cervical cancer is the second most common cancer among women worldwide, with approximately 85% of the disease burden occurring in developing countries. To date, there have been few systematic efforts to document African women's conceptualization of cervical cancer after participation in a visual inspection with acetic acid (VIA)-based " see and treat" cervical cancer prevention program. In this study, conducted between September, 2009-July, 2010, focus groups and in-depth interviews were conducted with 60 women who had recently undergone cervical cancer screening at a government-operated primary health care clinic in Lusaka, Zambia. Interviewers elicited participants' causal representations of cervical cancer, associated physical signs and symptoms, perceived physical and psychological effects, and social norms regarding the disease. The lay model of illness causation portrayed by participants after recent exposure to program promotion messages departed in several ways from causal models described in other parts of the world. However, causal conceptualizations included both lay and biomedical elements, suggesting a possible shift from a purely traditional causal model to one that incorporates both traditional concepts and recently promoted biomedical concepts. Most, but not all, women still equated cervical cancer with death, and perceived it to be a highly stigmatized disease in Zambia because of its anatomic location, dire natural course, connections to socially-condemned behaviors, and association with HIV/AIDS. No substantive differences of disease conceptualization existed according to HIV serostatus, though HIV positive women acknowledged that their immune status makes them more aware of their health and more likely to seek medical attention. Further attention should be dedicated to the processes by which women incorporate new knowledge into their representations of cervical cancer

Small x resummation in collinear factorisation

The summation of the small x-corrections to hard-scattering QCD amplitudes by collinear factorisation method is reconsidered and the K-factor is derived in leading ln x approximation with a result differing from the corresponding expression by Catani and Hautmann (Nucl. Phys. B 427, 475, 1994). The significance of the difference is demonstrated in the examples of structure function F_L and of exclusive vector meson electroproduction. The formulation covers the channels of non-vanishing conformal spin n paving the way for new applications.Comment: 34 pages, 6 figure

Motivations and experiences of women who accessed "see and treat" cervical cancer prevention services in Zambia

Background: In Zambia, a country with a generalized HIV epidemic, age-adjusted cervical cancer incidence is among the highest worldwide. In 2006, the University of Alabama at Birmingham-Center for Infectious Disease Research in Zambia and the Zambian Ministry of Health launched a visual inspection with acetic acid (VIA) -based "see and treat" cervical cancer prevention program in Lusaka. All services were integrated within existing government-operated primary health care facilities. Objective: Study aims were to (i) identify women's motivations for cervical screening, (ii) document women's experiences with screening and (iii) describe the potentially reciprocal influences between women undergoing cervical screening and their social networks. Design and methods: Focus group discussions (FGD) and in-depth interviews (IDI) were conducted with women who accepted screening and with care providers. Low-level content analysis was performed to identify themes evoked by participants. Between September 2009 and July 2010, 60 women and 21 care providers participated in 8 FGD and 10 IDI. Results: Women presented for screening with varying needs and expectations. A majority discussed their screening decisions and experiences with members of their social networks. Key reinforcing factors and obstacles to VIA screening were identified. Conclusions: Interventions are needed to gain support for the screening process from influential family members and peers

Density-functional embedding using a plane-wave basis

The constrained electron density method of embedding a Kohn-Sham system in a substrate system (first described by P. Cortona, Phys. Rev. B {\bf 44}, 8454 (1991) and T.A. Wesolowski and A. Warshel, J. Phys. Chem {\bf 97}, 8050 (1993)) is applied with a plane-wave basis and both local and non-local pseudopotentials. This method divides the electron density of the system into substrate and embedded electron densities, the sum of which is the electron density of the system of interest. Coupling between the substrate and embedded systems is achieved via approximate kinetic energy functionals. Bulk aluminium is examined as a test case for which there is a strong interaction between the substrate and embedded systems. A number of approximations to the kinetic-energy functional, both semi-local and non-local, are investigated. It is found that Kohn-Sham results can be well reproduced using a non-local kinetic energy functional, with the total energy accurate to better than 0.1 eV per atom and good agreement between the electron densities.Comment: 11 pages, 4 figure